Stem-oriented education is one of the inevitable trends of world education in order to improve the quality of human resources in the 4.0 Industrial era. In this orientation, learners have many opportunities to apply their knowledge into practice, know how to apply and synthesize knowledge of science, technology, technology and mathematics to create products on demand within their ability. Currently, stem education in vietnam has gradually been applied to a number of subjects at all educational levels. Science curriculum in elementary schools has very suitable content in stem orientation. In this study, we conduct a research on theoretical basis and design teaching process for some contents under the topic “material and energy”in the science program of grade 5 oriented to stem education which contributes to the improvement of teaching science subjects at elementary schools. Published under licence by iop publishing ltd.